Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats
Li-Jun Xue, Ju-Qiang Han, Yuan-Chen Zhou, Hong-Ye Peng, Teng-Fei Yin, Kai-Min Li, Shu-Kun Yao
Li-Jun Xue, Shu-Kun Yao, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
Ju-Qiang Han, Department of Hepatology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China
Yuan-Chen Zhou, Hong-Ye Peng, Teng-Fei Yin, Kai-Min Li, Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Xue LJ, Zhou YC, Peng HY and Yin TF performed the experiments; Xue LJ analyzed the data, prepared figures and contributed to the drafting of the manuscript; Yao SK and Han JQ supervised this work and edited and revised manuscript; Yao SK initiated the project, design the experiments and approved the final version of manuscript; Li KM provided technical assistance; All authors read and approved the final manuscript.
Supported by Science and Technology Project Task Book of Beijing, No. Z171100001717008.
Institutional animal care and use committee statement: The study was approved by the Animal Care Committees at China-Japan Friendship Hospital (Approval No: 190201).
Conflict-of-interest statement: All authors report no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the first author at lijuner_080629@163.com.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Received: August 17, 2020
Peer-review started: August 17, 2020
First decision: October 18, 2020
Revised: October 27, 2020
Accepted: November 9, 2020
Article in press: November 9, 2020
Published online: December 14, 2020