Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2020; 26(39): 6047-6056
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.6047
Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism
Masaki Inoue, Yuichi Shimizu, Marin Ishikawa, Satoshi Abiko, Yoshihiko Shimoda, Ikko Tanaka, Sayoko Kinowaki, Masayoshi Ono, Keiko Yamamoto, Shoko Ono, Naoya Sakamoto
Masaki Inoue, Yoshihiko Shimoda, Ikko Tanaka, Sayoko Kinowaki, Naoya Sakamoto, Department of Gastroenterology and Hepatology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido 060-0808, Japan
Yuichi Shimizu, Masayoshi Ono, Keiko Yamamoto, Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido 060-8648, Japan
Marin Ishikawa, Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-0808, Japan
Marin Ishikawa, Shoko Ono, Department of Gastroenterology, Hokkaido University Hospital, Sapporo, Hokkaido 060-8648, Japan
Satoshi Abiko, Department of Gastroenterology and Hepatology, Hakodate Municipal Hospital, Hakodate, Hokkaido 041-8680, Japan
Author contributions: Inoue M and Shimizu Y contributed equally to this work; Shimizu Y designed the research study; Inoue M, Shimoda Y, Tanaka I, Kinowaki S performed the research; Shimizu Y, Ono M, Yamamoto K, Ono S and Sakamoto N supervised the research; Inoue M, Shimizu Y and Abiko S analyzed data; Ishikawa M pathologically supervised the reseach; Inoue M and Shimizu Y wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: This study was reviewed and approved by Hokkaido University Hospital Division of Clinical Research Administration.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. For full disclosure, the details of the study are published on the home page of Hokkaido University.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yuichi Shimizu, MD, PhD, Associate Professor, Division of Endoscopy, Hokkaido University Hospital, kita 14 jo, nishi 5 chome, kita-ku, Sapporo, Hokkaido 060-8648, Japan.
Received: July 1, 2020
Peer-review started: July 1, 2020
First decision: July 28, 2020
Revised: August 13, 2020
Accepted: September 25, 2020
Article in press: September 25, 2020
Published online: October 21, 2020
Core Tip

Core Tip: We examined esophageal squamous cell carcinoma (ESCC) tissues obtained by endoscopic mucosal resection or endoscopic submucosal dissection for human papillomavirus (HPV) infection. Genotyping of alcohol dehydrogenase-1B (ADH1B)/ aldehyde dehydrogenase-2 (ALDH2) by using saliva sampling was performed. As a result, significant differences were not found between HPV infection and ADH1B/ALDH2. However, results of investigations including investigation of genetic polymorphisms in alcohol metabolism were shown for the first time, and there has so far been study on only early ESCC. We therefore consider the results of our study to be important.