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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2020; 26(35): 5287-5301
Published online Sep 21, 2020. doi: 10.3748/wjg.v26.i35.5287
Published online Sep 21, 2020. doi: 10.3748/wjg.v26.i35.5287
Immune infiltration-associated serum amyloid A1 predicts favorable prognosis for hepatocellular carcinoma
Wei Zhang, Hui-Fang Kong, Xu-Dong Gao, Zheng Dong, Ying Lu, Jia-Gan Huang, Yong-Ping Yang, Center for Diagnosis and Research of Liver Tumor, Fifth Medical Center of People's Liberation Army General Hospital, Beijing 100191, China
Hong Li, Department of Infectious Diseases, the Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China
Author contributions: Zhang W and Kong HF conducted data analysis, wrote the manuscript, and contributed equally to this study; Gao XD and Huang JG conducted the literature research and data collection; Dong Z, Lu Y and Li H discussed the results and statistical analysis; Yang YP designed the study and revised the manuscript.
Supported by Guizhou Provincial Natural Science Foundation , No. 2020-1Y299 .
Institutional review board statement: This study was approved by the Ethical committee of the Fifth Medical Center of People's Liberation Army General Hospital.
Conflict-of-interest statement: All authors have nothing to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong-Ping Yang, MD, Chief Doctor, Center for Diagnosis and Research of Liver Tumor, Fifth Medical Center of People's Liberation Army General Hospital, No. 100 West Sihuan Road, Fengtai District, Beijing 100191, China. yyp1542@163.com
Received: May 10, 2020
Peer-review started: May 10, 2020
First decision: July 29, 2020
Revised: August 3, 2020
Accepted: August 13, 2020
Article in press: August 13, 2020
Published online: September 21, 2020
Peer-review started: May 10, 2020
First decision: July 29, 2020
Revised: August 3, 2020
Accepted: August 13, 2020
Article in press: August 13, 2020
Published online: September 21, 2020
Core Tip
Core Tip: In this study, we identified the downregulation of serum amyloid A1 (SAA1) in hepatocellular carcinoma (HCC). SAA1 expression could predict the favorable prognosis for HCC patients, especially for those patients without hepatitis virus infection. SAA1 expression was closely associated with anti-tumor immune signaling pathways. We also identified two signature genes associated with SAA1, suggesting a favorable prognosis function of SAA1 for HCC patients.