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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2020; 26(3): 366-374
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.366
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.366
Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs: A case report
Nguyen Hai Nam, Kojiro Taura, Shinji Uemoto, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan
Masashi Kanai, Keita Fukuyama, Department of Clinical Oncology, Pharmacogenomics, and Palliative Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Norimitsu Uza, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Hirona Maeda, Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606-8507, Japan
Yojiro Yutaka, Toyofumi F Chen-Yoshikawa, Department of Thoracic. Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Manabu Muto, Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Author contributions: Nam NH and Taura K designed this report, reviewed the literature and contributed to manuscript drafting; Taura K and Uemoto S were the patient’s HPB surgeons; Maeda H performed the pathological examination; Yutaka Y and Chen-Yoshikawa TF were the patient’s thoracic surgeons; Kanai M, Fukuyama K, Muto M performed the genomic profiling analysis using whole exome sequencing; Nam NH, Taura K and Uza N were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kojiro Taura, MD, PhD, Associate Professor, Doctor, Surgeon, Surgical Oncologist, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. ktaura@kuhp.kyoto-u.ac.jp
Received: October 13, 2019
Peer-review started: October 13, 2019
First decision: December 5, 2019
Revised: December 13, 2019
Accepted: December 22, 2019
Article in press: December 22, 2019
Published online: January 21, 2020
Peer-review started: October 13, 2019
First decision: December 5, 2019
Revised: December 13, 2019
Accepted: December 22, 2019
Article in press: December 22, 2019
Published online: January 21, 2020
Core Tip
Core tip: An intraductal papillary neoplasm of the bile duct without an invasive component has unexpectedly metastasized to the brain and lungs. In addition to histopathological results, a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer by detecting 100 single nucleotide variants and 168 insertion/deletions.