©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Conservation and variability of hepatitis B core at different chronic hepatitis stages
Marçal Yll, Maria Francesca Cortese, Gerard Orriols, Rosario Casillas, Carolina González, Sara Sopena, Cristina Godoy, Marta Vila, David Tabernero, Ariadna Rando, Rosa Lopez-Martinez, Francisco Rodríguez-Frías, Liver Pathology Unit, Departments of Biochemistry and Microbiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona 08035, Spain
Marçal Yll, Maria Francesca Cortese, Mercedes Guerrero-Murillo, Josep Gregori, Rosario Casillas, Sara Sopena, Marta Vila, Josep Quer, Francisco Rodríguez-Frías, Liver Unit, Liver Disease Laboratory-Viral Hepatitis, Vall d'Hebron Institut Recerca-Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona 08035, Spain
Mercedes Guerrero-Murillo, Department of Microbiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona 08035, Spain
Josep Gregori, Cristina Godoy, David Tabernero, Josep Quer, Rafael Esteban, Mar Riveiro-Barciela, Maria Buti, Francisco Rodríguez-Frías, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid 28029, Spain
Rafael Esteban, Mar Riveiro-Barciela, Maria Buti, Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona 08035, Spain
Author contributions: Rodríguez-Frías F designed the research; Cortese MF coordinated the research; Yll M and Cortese MF equally contributed to design the experiments; Yll M, Orriols G, Godoy C, Sopena S, Casillas R, González C, Vila M and Rando A performed the experiments; Yll M, Cortese MF, Gregori J and Guerrero-Murillo M analyzed data acquired during the experiments and interpreted the results; Yll M and Cortese MF drafted the manuscript; Cortese MF, Tabernero D, Lopez-Martinez R, Riveiro-Barciela M, Buti M, Quer J, Esteban R and Rodríguez-Frías F critically reviewed the manuscript.
Supported by the Instituto de Salud Carlos III, Spain, the European Regional Development Fund, No. PI18/01436.
Institutional review board statement: The study was reviewed and approved by the Clinical Research Ethics Committee of Hospital Universitari Vall d’Hebron.
Conflict-of-interest statement: Josep Gregori is an employee of Roche Diagnostics, SL.
Data sharing statement: Next-generation sequencing data were submitted to the GenBank SRA database (BioProject accession number PRJNA625435).
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Maria Francesca Cortese, PhD, Research Scientist, Liver Pathology Unit, Departments of Biochemistry and Microbiology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain. email@example.com
Received: February 28, 2020
Peer-review started: February 28, 2020
First decision: April 9, 2020
Revised: May 8, 2020
Accepted: May 19, 2020
Article in press: May 19, 2020
Published online: May 28, 2020