Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model
Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo
Bruna Girardi, Maria Pricci, Floriana Giorgio, THD SpA, Correggio 42015, Italy
Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy
Author contributions: Di Leo A, Ierardi E and Barone M planned the study; Girardi B, Pricci M, Giorgio F, Piazzolla M took care of mice; Girardi B, Pricci M, Giorgio F, Piazzolla M, Losurdo G, Iannone A collected the data; Girardi B, Pricci M, Giorgio F, Piazzolla M performed experimental analysis; Ierardi E and Girardi B performed histological analysis; Iannone A and Losurdo G performed statistical analysis; Girardi B and Ierardi E wrote the paper; All Authors read and approved the final version.
Institutional review board statement: The study protocol was approved by the University of Bari Ethics committee (protocol number 6/12).
Institutional animal care and use committee statement: The study protocol was approved by the University of Bari Committee for Animal Experimentation (protocol number 6/12).
Conflict-of-interest statement: Alfredo Di Leo is an advisory board member of THD S.p.a. Floriana Giorgio, Bruna Girardi and Maria Pricci are employees of THD S.p.a. All the other authors declare no financial support or conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Alfredo Di Leo, MD, PhD, Full Professor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. alfredo.dileo@uniba.it
Received: December 7, 2019
Peer-review started: December 7, 2019
First decision: December 30, 2019
Revised: March 6, 2020
Accepted: March 27, 2020
Article in press: March 27, 2020
Published online: April 14, 2020
