Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1601
Peer-review started: December 7, 2019
First decision: December 30, 2019
Revised: March 6, 2020
Accepted: March 27, 2020
Article in press: March 27, 2020
Published online: April 14, 2020
Some natural products derived from plants may have anti-carcinogenetic effect.
We looked for possible candidate molecules to arrest the development of intestinal cancer in an animal model.
To test a combination of phytochemicals in a mouse model of genetic intestinal carcinogenesis.
A combination of silymarin, boswellic acid and curcumin was given to forty adenomatous polyposis coli multiple intestinal neoplasia. Markers of proliferation/apoptosis were examined.
Compared to standard, enriched diet reduced the total number of polypoid lesions. In enriched diet group a reduction in polyp size was observed. Areas of low-grade dysplasia and intestinal carcinoma were significantly decreased in enriched diet group. Enriched diet showed a faster epithelial migration and an increased apoptosis in normal mucosa and low-grade dysplasia areas. Estrogen receptor beta protein was well expressed in normal mucosa of enriched and standard groups, with a more marked trend associated to the first one. Estrogen receptor alpha was similarly expressed in normal and polypoid mucosa of standard and enriched diet group. Cleaved caspase 3 showed in normal mucosa a stronger signal in enriched than in standard diet. Cyclin D1 was more expressed in standard than enriched diet group of both normal and polypoid tissue.
Our results are suggestive of a chemo-preventive synergic effect of silymarin, boswellic acid and curcumin in inherited intestinal cancer.
The dietetic formulation may be promising for patients with a genetic predisposition to develop intestinal polyps and carcinomas.