Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition
Qing-Ge Lu, Li Zeng, Xiao-Hai Li, Yu Liu, Xue-Feng Du, Guo-Min Bai, Department of Anorectal, Tangshan Traditional Chinese Medicine Hospital, Tangshan 063000, Hebei Province, China
Xin Yan, College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan 063210, Hebei Province, China
Author contributions: Lu QG and Zeng L designed the research; Li XH and Liu Y performed the research; Du XF and Bai GM analyzed the data; Yan X wrote the paper.
Supported by National Natural Science Foundation of China, No. 81704059; Scientific Research Project of Hebei Province Traditional Chinese Medicine Administration, No. 2017130.
Institutional review board statement: This study was reviewed and approved by the North China University of Science and Technology Ethics Committee (Approval No. NCST2018196).
Institutional animal care and use committee statement: This study was reviewed and approved by the Animal Care Welfare Committee of North China University of Science and Technology (No. 20180809).
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xin Yan, PhD, Professor, College of Traditional Chinese Medicine, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan 063210, Hebei Province, China. firstname.lastname@example.org
Received: November 12, 2019
Peer-review started: November 12, 2019
First decision: December 23, 2019
Revised: December 27, 2019
Accepted: February 21, 2020
Article in press: February 21, 2020
Published online: March 21, 2020