MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes
Moustafa Nouh Elemeery, Département de Neurosciences, CRCHUM, Université de Montréal, Montréal, Quebec H2X 3E4, Canada
Moustafa Nouh Elemeery, Medical Biotechnology Laboratory, Genetic Engineering and Biotechnology Research Division, National Research Centre, Cairo 12622, Egypt
Moustafa Nouh Elemeery, Cheol-Ho Pan, Natural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung 25451, South Korea
Moustafa Nouh Elemeery, Cheol-Ho Pan, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea
Marwa Anwar Mohamed, Department of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria 21511, Egypt
Marwa Ahmed Madkour, Mohammed Mohammed Shamseya, Experimental and Clinical Internal Medicine Department, Medical Research Institute, Alexandria University, Alexandria 21511, Egypt
Noha Mahmoud Issa, Human Genetics Department, Medical Research Institute, Alexandria University, Alexandria 21511, Egypt
Ahmed Noah Badr, Food Toxicology and Contaminates Department, National Research Centre, Dokki, Cairo 12622, Egypt
Doaa Ahmed Ghareeb, Bioscreening and preclinical trial lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 12522, Egypt
Doaa Ahmed Ghareeb, Pharmaceutical and fermentation industries development center, the city of scientific research and technological applications, Alexandria 26411, Egypt
Author contributions: Elemeery MN designed the research, performed the laboratory work, and drafted the manuscript; Mohamed MA and Issa NM supplied reagents and performed the laboratory work; Madkour MA performed the case selection and the clinical and radiological evaluations, and drafted the manuscript; Shamseya MM performed the case selection and the clinical and radiological evaluations; Badr AN performed the data analysis and biological parameter assessment; Ghareeb DA performed the RT-qPCR work; Pan CH supplied reagents and designed the primers; All authors contributed equally to the manuscript revision.
Institutional review board statement: The study was approved by the ethical committees of the Medical Research Institute of Alexandria University; the National Hepatology and Tropical Medicine Research Institute (NHTMRI, Giza, Egypt); and the National Research Centre (NRC, Cairo, Egypt).
Informed consent statement: All patients provided informed consent.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email@example.com.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cheol-Ho Pan, PhD, Professor, Natural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Saimdang-ro, Gangneung 25451, South Korea. firstname.lastname@example.org
Received: September 3, 2019
Peer-review started: September 3, 2019
First decision: October 14, 2019
Revised: October 29, 2019
Accepted: November 7, 2019
Article in press: November 7, 2019
Published online: November 14, 2019