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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2019; 25(36): 5515-5529
Published online Sep 28, 2019. doi: 10.3748/wjg.v25.i36.5515
Published online Sep 28, 2019. doi: 10.3748/wjg.v25.i36.5515
Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma
Qiang Wang, Xiao-Lan Lu, Qin Du, Guo-Yuan Zhang, Dong-Sheng Wang, Qu-Ming Fan, Department of Laboratory Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Qiang Wang, Faculty of Laboratory Medicine, Center for Translational Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Qi Chen, Department of Laboratory Medicine, Affiliated Sichuan Ba-Yi Rehabilitation Center of Chengdu University of TCM, Chengdu 610000, Sichuan Province, China
Xia Zhang, Department of Laboratory Medicine of the Ninth People’s Hospital of Chongqing, Chongqing 400700, China
Tao Zhu, Department of Preventive Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Author contributions: All authors contributed to the conceptualisation and design of the study; Wang Q, Chen Q, and Zhang X contributed to the clinical data collection and analysis, and prepared and wrote the first draft of this manuscript; Lu XL, Du Q, and Zhang GY contributed to the clinical data collection; Zhu T contributed to the statistical analysis; Wang DS and Fan QM designed this study and revised the manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Affiliated Hospital of North Sichuan Medical College.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agree to treatment by written consent.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qu-Ming Fan, PhD, Research Assistant Professor, Department of Laboratory Medicine, Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong 637000, Sichuan Province, China. fanqum@163.com
Telephone: +86-817-2190089 Fax: +86-817-2222856
Received: July 25, 2019
Peer-review started: July 25, 2019
First decision: August 17, 2019
Revised: August 25, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: September 28, 2019
Peer-review started: July 25, 2019
First decision: August 17, 2019
Revised: August 25, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: September 28, 2019
Core Tip
Core tip: This study showed that the ratio of gamma-glutamyltransferase to aspartate aminotransferase (γ-GT/AST ratio) was not correlated with tumour size in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and there was no difference in the AUROC between early-stage HBV-related HCC and HBV-related HCC, indicating that the γ-GT/AST ratio may be more useful than protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) in the diagnosis of early-stage HBV-related HCC. PIVKA-II and AFP combined with the γ-GT/AST ratio can enhance the diagnostic value of these biomarkers in different categories of HBV-related HCC.