Qin Zhao, Lei-Qi Xu, Xiao Cui, Xiu-Li Zuo, Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Qin Zhao, Xiao-Hong Wang, Gai-Qin Li, Department of Gastroenterology, Taian City Central Hospital, Taian 271000, Shandong Province, China
Wen-Rong Yang, Department of Clinical Nutrition, Taian City Central Hospital, Taian 271000, Shandong Province, China
Yang Liu, Department of Medicine, Beijing 316 Hospital, Beijing 100093, China
Author contributions: Zhao Q, Zuo XL and Xu LQ formulated the study concept, designed the study, and guaranteed the integrity of the entire study; Zhao Q and Cui X contributed to experimental studies and data acquisition; Zhao Q, Cui X, and Xu LQ contributed to literature research and manuscript editing; Zhao Q contributed to definition of intellectual content and clinical studies and manuscript preparation; Zhao Q, Cui X, Wang XH, and Yang WR contributed to data analysis; Zhao Q, Cui X, Wang XH, Li GQ, and Liu Y contributed to statistical analysis; Zuo XL and Xu LQ contributed to manuscript review; all authors approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 81770538 and No. 81570485; and Key Research and Development Program of Shandong Province, No. 2017CXGC1215.
Institutional animal care and use committee statement: This study was approved by the Institutional Animal Ethical Review Board of Taian City Central Hospital.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this manuscript or its publication.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiu-Li Zuo, MD, PhD, Associate Professor, Chief Doctor, Department of Gastroenterology, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. firstname.lastname@example.org
Telephone: +86-531-88369277 Fax: +86-531-88369277
Received: July 10, 2019
Peer-review started: July 10, 2019
First decision: August 5, 2019
Revised: August 17, 2019
Accepted: August 24, 2019
Article in press: August 24, 2019
Published online: September 28, 2019