Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2019; 25(35): 5283-5299
Published online Sep 21, 2019. doi: 10.3748/wjg.v25.i35.5283
Published online Sep 21, 2019. doi: 10.3748/wjg.v25.i35.5283
Long non-coding RNA highly up-regulated in liver cancer promotes exosome secretion
Shun-Qi Cao, Dong-Hui Guo, Tianjin First Central Hospital Clinic Institute, Tianjin Medical University, Tianjin 300070, China
Hong Zheng, Zhong-Yang Shen, Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China
Bao-Cun Sun, Department of Pathology, Tianjin Medical University, Tianjin 300070, China
Zheng-Lu Wang, Department of Pathology, Tianjin First Central Hospital, Tianjin 300192, China
Tao Liu, NHC Key Laboratory of Critical Care Medicine, Tianjin First Central Hospital, Tianjin 300192, China
Author contributions: Cao SQ, Zheng H, Sun BC, Wang ZL, and Liu T performed the research, analysed the data, and wrote and revised the manuscript; Shen ZY designed the study and participated in the revision of the article; all authors have read and approved the final manuscript.
Supported by Tianjin Clinical Research Center for Organ Transplantation Project , No. 15ZXLCSY00070 ; and The Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences , No. 2018PT32021 .
Institutional review board statement: The study was reviewed and approved by the Tianjin First Central Hospital Medical Ethics Committee.
Conflict-of-interest statement: The authors declare no potential conflict of interest in this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhong-Yang Shen, MD, PhD, Professor, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24, Fukang Road, Nankai District, Tianjin 300192, China. shen_zhongyang@126.com
Telephone: +86-22-2362698 Fax: +86-22-2362698
Received: April 26, 2019
Peer-review started: April 26, 2019
First decision: May 24, 2019
Revised: June 7, 2019
Accepted: July 19, 2019
Article in press: May 24, 2019
Published online: September 21, 2019
Peer-review started: April 26, 2019
First decision: May 24, 2019
Revised: June 7, 2019
Accepted: July 19, 2019
Article in press: May 24, 2019
Published online: September 21, 2019
Core Tip
Core tip: We found that (1) HULC expression was higher in serum exosomes of patients with HCC than in those of healthy controls, and higher in liver cancer tissues than in tumor adjacent tissues; (2) HULC expression in serum exosomes and liver cancer tissues were correlated with the TNM classification, and HULC expression in tissues was correlated with that in serum exosomes; (3) Increased HULC expression was associated with increased proliferation and invasion and reduced apoptosis of HCC cells; and (4) HULC repressed miR-372-3p expression, and miR-372-3p could directly bind both HULC and Rab11a. Furthermore, the HULC/ miR-372-3p /Rab11a axis promoted the secretion of exosomes from HCC cells.