Clinical Trials Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2019; 25(34): 5185-5196
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5185
Overlay of a sponge soaked with ropivacaine and multisite infiltration analgesia result in faster recovery after laparoscopic hepatectomy
Hao Zhang, Gang Du, Yan-Feng Liu, Jin-Huan Yang, Mu-Guo A-Niu, Xiang-Yu Zhai, Bin Jin
Hao Zhang, Gang Du, Yan-Feng Liu, Jin-Huan Yang, Mu-Guo A-Niu, Xiang-Yu Zhai, Bin Jin, Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Zhang H and Du G collected the data and drafted the manuscript; A-Niu MG, Liu YF, and Zhai XY contributed to data collection and statistical analysis; Yang JH helped revise the manuscript; Jin B contributed to the study design and revised the manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81571367; and Technological Project of Shandong Province, No. 2017GSF218021.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Qilu Hospital of Shandong University (No. 2017052).
Clinical trial registration statement: This study is registered at []. The registration identification number is [ChiCTR1900020630].
Informed consent statement: All involved patients provided informed consent prior to the study inclusion.
Conflict-of-interest statement: We declare that we have no conflicts of interest.
Data sharing statement: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Bin Jin, MD, PhD, Chief Doctor, Professor, Surgeon, Department of general Surgery, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Lixia, Jinan 250012, Shandong Province, China.
Telephone: +86-18366116329
Received: May 17, 2019
Peer-review started: May 17, 2019
First decision: July 21, 2019
Revised: August 4, 2019
Accepted: August 19, 2019
Article in press: August 19, 2019
Published online: September 14, 2019
Core Tip

Core tip: This study confirmed the efficacy of ropivacaine in pain control after laparoscopic hepatectomy and its contribution to fast track recovery surgery. Ropivacaine not only infiltrated the subcutaneous and deep muscle fasciae and peritoneum but also covered the liver cutting surface in a soaked gelatin sponge to relieve the pain caused by capsule injury. We examined the efficacy using not only visual analog scale, but also blood biochemistry and other standards.