Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5097
Peer-review started: May 28, 2019
First decision: July 21, 2019
Revised: July 26, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 14, 2019
Core tip: The most adequate acid suppression by proton pump inhibitors (PPIs) is fundamental to optimize antibiotic therapies for Helicobacter pylori eradication. Herein, we summarize data from literature in order to ascertain the most effective strategies in this topic. Increasing PPI dose showed a real benefit on eradication rate even in the absence of dedicated trials. Second-generation PPIs, as demonstrated in some meta-analyses, may be more effective than old PPI molecules. Finally, vonoprazan, a novel molecule, has shown promising results but, currently, data come from Asian countries, therefore its strong power needs to be confirmed outside this geographic area.