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World J Gastroenterol. Jul 14, 2019; 25(26): 3359-3369
Published online Jul 14, 2019. doi: 10.3748/wjg.v25.i26.3359
Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer
Guo-Qing Zhang, Li-Ping Zhong, Nuo Yang, Yong-Xiang Zhao
Guo-Qing Zhang, Li-Ping Zhong, Nuo Yang, Yong-Xiang Zhao, National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhang GQ, Zhong LP, Yang N, and Zhao YX wrote the paper.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong-Xiang Zhao, MD, PhD, Full Professor, National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. yongxiang_zhao@126.com
Telephone: +86-15177120015 Fax: +86-771-5317061
Received: May 18, 2019
Peer-review started: May 18, 2019
First decision: May 30, 2019
Revised: June 2, 2019
Accepted: June 8, 2019
Article in press: June 8, 2019
Published online: July 14, 2019
Core Tip

Core tip: For liver cancer, conventional diagnostic methods have low sensitivity, therapeutic drugs have great side effects, and tumor monitoring is difficult, which limit the diagnosis and treatment of liver cancer. However, the diagnosis and treatment of liver cancer based on aptamers have great application prospects. This review describes the screening of aptamers and reviews the recent advances on aptamers in the targeted diagnosis and treatment of liver cancer.