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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2019; 25(24): 3056-3068
Published online Jun 28, 2019. doi: 10.3748/wjg.v25.i24.3056
Published online Jun 28, 2019. doi: 10.3748/wjg.v25.i24.3056
Freeze-dried Si-Ni-San powder can ameliorate high fat diet-induced non-alcoholic fatty liver disease
Feng Zhu, Yong-Min Li, Ting-Ting Feng, Yue Wu, Hai-Xia Zhang, Guo-Yin Jin, Department of Traditional Chinese Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Jian-Ping Liu, Department of Gastroenterology, People’s Hospital of Changshou District, Chongqing 401220, China
Author contributions: Li YM designed the research; Zhu F, Feng TT, Wu Y and Jin GY performed the research; Liu JP analyzed and interpreted the data; Liu JP and Zhang HX wrote the paper.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the animal ethics committee of Hebei North University, Zhangjiakou, China (No.2016-1-0-06).
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: Raw sequencing data are available from the corresponding author. Participants gave informed consent for data sharing.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong-Min Li, MD, PhD, Full Professor, Department of Traditional Chinese Medicine, Hebei North University, No. 11, Diamond South Road, Zhangjiakou 075000, Hebei Province, China. zyxylym@hebeinu.edu.cn
Telephone: +86-313-4029228 Fax: +86-313-4029228
Received: February 21, 2019
Peer-review started: February 22, 2019
First decision: February 26, 2019
Revised: May 28, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: June 28, 2019
Peer-review started: February 22, 2019
First decision: February 26, 2019
Revised: May 28, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: June 28, 2019
Core Tip
Core tip: We studied the effects of Si-Ni-San freeze-dried powder on high fat diet-induced nonalcoholic fatty liver disease (NAFLD) in mice. We found that Si-Ni-San freeze-dried powder ameliorated high fat diet-induced NAFLD in mice, and the mechanism of action of Si-Ni-San freeze-dried powder against NAFLD may be associated with its anti-inflammatory and changing intestinal microbiota effects. Our findings provide some useful information for therapy of NAFLD.