Risk factors for progression to acute-on-chronic liver failure during severe acute exacerbation of chronic hepatitis B virus infection
Ling Yuan, Bai-Mei Zeng, Yan-Qing Yang, Jun Chu, Ying Li, Fang-Wan Yang, Yi-Huai He, Shi-De Lin, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Lu-Lu Liu, Department of Gastroenterology, Jiangsu Province Hospital, Pukou Branch, Nanjing 210000, Jiangsu Province, China
Yi Ren, Department of Respiratory Medicine, the Fifth People’s Hospital of Chongqing, Chongqing 400062, China
Author contributions: Yuan L and Zeng BM contributed equally to this work; Yuan L, Zeng BM, Liu LL, Ren Y, Chu J, Yang YQ, and Lin SD performed the research; Yuan L and Zeng BM wrote the manuscript; He YH, Yang FW, Li Ying, and Lin SD performed the biostatistic analysis; Zeng BM, Liu LL, Ren Y, Chu J, Yang YQ, and Lin SD analyzed the data; all authors discussed the results and commented on the manuscript.
Supported by the National Natural Science Foundation of China, No. 81460124 and No. 81860114.
Institutional review board statement: This study was approved by the Institutional Review Board of Affiliated Hospital of Zunyi Medical University, Guizhou Province, China.
Informed consent statement: All patients were informed of the use of their data in writing for clinical research purposes and accepted.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest in this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shi-De Lin, MD, Chief Doctor, Occupational Physician, Professor, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, 201 Dalian street, Zunyi 563003, Guizhou Province, China. email@example.com
Telephone: +86-851-28609183 Fax: +86-851-28609183
Received: February 14, 2019
Peer-review started: February 17, 2019
First decision: March 20, 2019
Revised: March 29, 2019
Accepted: April 19, 2019
Article in press: April 20, 2019
Published online: May 21, 2019