Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2019; 25(16): 1986-1996
Published online Apr 28, 2019. doi: 10.3748/wjg.v25.i16.1986
Dual energy computed tomography for detection of metastatic lymph nodes in patients with hepatocellular carcinoma
Yu-Rong Zeng, Qi-Hua Yang, Qing-Yu Liu, Jun Min, Hai-Gang Li, Zhi-Feng Liu, Ji-Xin Li
Yu-Rong Zeng, Qi-Hua Yang, Qing-Yu Liu, Ji-Xin Li, Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Jun Min, Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Hai-Gang Li, Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Zhi-Feng Liu, Department of Radiology, Zengcheng District People’s Hospital of Guangzhou, Guangzhou 511300, Guangdong Province, China
Author contributions: Zeng YR and Yang QH contributed equally to this work; Zeng YR, Yang QH, and Liu QY designed the research; Zeng YR, Yang QH, Min J, Li HG, and Liu ZF performed the research; Li JX contributed technical guidance and operation; Zeng YR, Yang QH, Min J, and Liu ZF analyzed the data; Zeng YR, Yang QH, and Liu QY wrote the paper.
Institutional review board statement: The study was reviewed and approved by the institutional review board of Sun Yat-sen Memorial Hospital.
Informed consent statement: Informed consent was waived by the ethics committee of Sun Yat-sen Memorial Hospital.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qing-Yu Liu, PhD, Attending Doctor, Professor, Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou 510120, Guangdong Province, China. liuqy@mail.sysu.edu.cn
Telephone: +86-13694201711 Fax: +86-20-81332702
Received: February 2, 2019
Peer-review started: February 6, 2019
First decision: March 5, 2019
Revised: March 14, 2019
Accepted: March 24, 2019
Article in press: March 24, 2019
Published online: April 28, 2019
Core Tip

Core tip: Dual-energy computed tomography (CT) contributes beneficially to regional lymph node assessment in hepatocellular carcinoma (HCC) patients, which can differentiate metastatic and non-metastatic lymph nodes for improving regional lymph node staging of HCC. Combination of maximal short axis diameter with dual-energy CT quantifiable parameters (iodine concentration, normalized iodine concentration, or the slope of the spectral curve) in the portal phase can be more advantageous in regional lymph node assessment. Active hepatitis does not deteriorate the detection and characterization of metastatic lymph nodes in HCC.