Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions
Yang-Hui Bi, Wen-Qi Han, Ruo-Fei Li, Yun-Jiao Wang, Zun-Shu Du, Xue-Jiang Wang, Ying Jiang, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
Author contributions: Bi YH and Han WQ contributed equally to this work; Jiang Y and Wang XJ designed the research; Jiang Y, Bi YH, Han WQ, Li RF, Wang XJ, and Du ZS performed the research; Jiang Y contributed new reagents or analytic tools; Jiang Y, Bi YH, and Han WQ analyzed the data and wrote the paper; all of the authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81070319; the Beijing Natural Science Foundation of China, No. 7102013; and the Beijing Municipal Education Commission Research Program, China, No. KM201610025004.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Capital Medical University [IACUC protocol number: (AEEI-2016-118)].
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The manuscript has no additional data available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ying Jiang, PhD, Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Beijing 100069, China. firstname.lastname@example.org
Received: January 27, 2019
Peer-review started: January 27, 2019
First decision: February 26, 2019
Revised: March 7, 2019
Accepted: March 24, 2019
Article in press: March 25, 2019
Published online: April 28, 2019