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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2019; 25(15): 1854-1864
Published online Apr 21, 2019. doi: 10.3748/wjg.v25.i15.1854
Published online Apr 21, 2019. doi: 10.3748/wjg.v25.i15.1854
Extract of Cycas revoluta Thunb. enhances the inhibitory effect of 5-fluorouracil on gastric cancer cells through the AKT-mTOR pathway
Xing-Liang Cui, Hai-Xia Ren, Yong-Jian Zhang, Xiao-Dong Liu, Bao-Guo Bu, Department of Gastroenterology, Affiliated Hospital of Hebei University of Engineering, Handan 056001, Hebei Province, China
Ke-Ji Li, Department of Surgery, Affiliated Hospital of Hebei University of Engineering, Handan 056001, Hebei Province, China
Lei Wang, Department of Pathology, Medical College of Hebei University of Engineering, Handan 056000, Hebei Province, China
Author contributions: Wang L and Cui XL designed the research; Li KJ, Ren HX, Zhang YJ and Cui XL performed the research; Liu XD and Bu BG analyzed the data; Wang L and Cui XL wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Affiliated Hospital of Hebei University of Engineering.
Conflict-of-interest statement: We declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lei Wang, MA, MSc, Associate Professor, Department of Pathology, Medical College of Hebei University of Engineering, No. 42 Congtai Road, Handan 056000, Hebei Province, China. wangleinv1975@126.com
Telephone: +86-13131048342 Fax: +86-310-8575116
Received: February 21, 2019
Peer-review started: February 21, 2019
First decision: March 5, 2019
Revised: March 10, 2019
Accepted: March 16, 2019
Article in press: March 16, 2019
Published online: April 21, 2019
Peer-review started: February 21, 2019
First decision: March 5, 2019
Revised: March 10, 2019
Accepted: March 16, 2019
Article in press: March 16, 2019
Published online: April 21, 2019
Core Tip
Core tip: 5-fluorouracil (5-Fu) is an effective treatment for gastric cancer, which is one of the most common and deadly malignancies worldwide. However, the effect of 5-Fu is limited by the drug resistance of gastric cancer. Here, we report that natural extract of Cycas revoluta Thunb. effectively inhibits gastric cancer cell growth, migration and invasion. Furthermore, it can be used in combination with 5-Fu to enhance its anti-cancer effects through the AKT-mTOR pathway.