Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2018; 24(45): 5120-5130
Published online Dec 7, 2018. doi: 10.3748/wjg.v24.i45.5120
Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells
Qiang Fu, Chuan-Jiang Liu, Xu Zhang, Zhen-Sheng Zhai, Yu-Zhu Wang, Ming-Xing Hu, Xian-Ling Xu, Hong-Wei Zhang, Tao Qin
Qiang Fu, Chuan-Jiang Liu, Xu Zhang, Zhen-Sheng Zhai, Yu-Zhu Wang, Ming-Xing Hu, Xian-Ling Xu, Hong-Wei Zhang, Tao Qin, Department of Hepatobiliary and Pancreatic Surgery, People’s Hospital of Zhengzhou University (Henan Provincial People’s Hospital), School of Medicine, Zhengzhou University, Zhengzhou 450003, Henan Province, China
Author contributions: Fu Q and Zhang X performed the majority of experiments; Zhang HW and Qin T designed the research and provided financial support for this work; Liu CJ conducted the experimental analysis; Wang YZ provided vital reagents; Hu MX and Xu XL analyzed sequencing data and developed analysis tools; Fu Q and Qin T wrote the paper.
Supported by National Natural Science Foundation of China, No. 31671440.
Correspondence author to: Tao Qin, MD, PhD, Doctor, Professor, Department of Hepatobiliary and Pancreatic Surgery, People’s Hospital of Zhengzhou University (Henan Provincial People’s Hospital), School of Medicine, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou 450003, Henan Province, China. m18937638396@163.com
Telephone: +86-371-65580368 Fax: +86-371-65580368
Received: September 5, 2018
Peer-review started: September 5, 2018
First decision: October 24, 2018
Revised: November 12, 2018
Accepted: November 13, 2018
Article in press: November 13, 2018
Published online: December 7, 2018
Core Tip

Core tip: The severity of acute pancreatitis (AP) is inversely related to the rate of apoptosis of pancreatic acinar cells. MicroRNA-22 (miR-22) might promote caerulein-induced apoptosis of pancreatic acinar cells (AR42J) via down-regulating the expression of its target gene, Erb-b2 receptor tyrosine kinase 3 (ErbB3) and the PI3k/Akt signaling pathway. Glucocorticoid receptor transcriptionally repressed the expression of miR-22 by binding to the miR-22 promoter transcription start site. The upregulation of miR-22 expression resulting from silencing Nr3c1 contributed to the apoptosis of AR42J cells.