Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2018; 24(44): 5046-5056
Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.5046
Prognostic value of fibrinogen and D-dimer-fibrinogen ratio in resectable gastrointestinal stromal tumors
Hua-Xia Cai, Xu-Qi Li, Shu-Feng Wang
Hua-Xia Cai, Xu-Qi Li, Shu-Feng Wang, Department of General Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Hua-Xia Cai, Department of General Surgery, Xi’an 141 Hospital, Yanliang 710089, Shaanxi Province, China
Author contributions: Cai HX and Wang SF designed the study; Cai HX analyzed and interpreted the data and drafted the manuscript; Li XQ and Wang SF revised the controversial parts of the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Xi’an Jiaotong University.
Informed consent statement: All the patients or their legal guardians signed informed consent before the operation. Since this study used anonymous clinical data, patients did not need to give informed consent.
Conflict-of-interest statement: There was no conflict of interest in the present study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author to: Shu-Feng Wang, MD, PhD, Doctor, Full Professor, Surgeon, Department of General Surgery, First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an 710061, Shaanxi province, China.
Telephone: +86-18991232452
Received: August 17, 2018
Peer-review started: August 17, 2018
First decision: October 14, 2018
Revised: October 27, 2018
Accepted: November 9, 2018
Article in press: November 9, 2018
Published online: November 28, 2018
Core Tip

Core tip: For patients with gastrointestinal stromal tumors (GISTs), postoperative recurrence and metastasis are the main factors affecting survival. Moreover, recurrence and metastasis mainly occur in moderate and high-risk patients. Therefore, it is necessary to screen these patients for adjuvant treatment at an early stage. Fibrinogen (FIB) and D-dimer were reported to be associated with the prognosis of many tumors. The purpose of this study was to investigate the value of preoperative FIB, D-dimer, the D-dimer-fibrinogen ratio (DFR), and platelets in the prognosis of GISTs. The results showed that FIB and DFR were independent risk factors for predicting the prognosis of primary resectable GIST.