Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.5046
Peer-review started: August 17, 2018
First decision: October 14, 2018
Revised: October 27, 2018
Accepted: November 9, 2018
Article in press: November 9, 2018
Published online: November 28, 2018
It is well known that moderate and high-risk gastrointestinal stromal tumor (GIST) patients have a high recurrence rate and need adjuvant targeted therapy to improve prognosis. Therefore, early screening of this protion of patients to give adjuvant treatment is particularly important. At present, the prediction of GISTs is obtained by postoperative pathology, and there is no effective index to predict the prognosis of GISTs before operation. The purpose of this retrospective study was to investigate the role of fibrinogen (FIB), D-dimer-fibrinogen ratio (DFR) in the prognosis of GISTs before operation.
The increase of blood coagulation indexes such as fibrinogen content and D-dimer before operation can predict the adverse prognosis of many kinds of cancer, but there is little discussion about the relationship between these indexes and GISTs.
The retrospective study analyzed the role of FIB, D-dimer, DFR, and platelet count (PLT) in the prognosis of GISTs before operation.
This study included 170 patients with GISTs who met the criteria. The data of all the patients were collected before and after operation to make statistical analysis. All data were analyzed using the SPSS 18.0 statistical software, with a P-value below 0.05 considered statistically significant.
In the present study, univariate analysis showed that FIB, D-dimer, DFR, and PLT were correlated with the 3- and 5-year survival rates of GIST patients. In addition, there was a correlation between the clinical features and FIB, D-dimer, DFR, and PLT in GISTs. Moreover, multivariate analysis showed that FIB and DFR had an independent effect on the prognosis of GIST patients.
This retrospective study showed that FIB, D-dimer, DFR, and PLT were the prognostic factors of GISTs, but there was an independent correlation between FIB and DFR and GIST prognosis. These factors may help screen out high-risk patients early and to administer adjuvant intervention as soon as possible.
For patients with GISTs, the prognosis can be preliminarily estimated according to hematological indexes such as FIB and DFR before the operation, and adjuvant therapy can be given early to improve the prognosis of patients. Of course, the results of this study need to be further verified by a large sample size prospective study.
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