Published online Sep 14, 2018. doi: 10.3748/wjg.v24.i34.3821
Peer-review started: May 21, 2018
First decision: June 13, 2018
Revised: June 22, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: September 14, 2018
Core tip: Prevalence of diabetic gastroparesis (DGP) is increasing in a dramatic fashion, however there are still gaps in our understanding of the pathophysiology of DGP. It well documented that gastric emptying and subsequent pancreatic secretion are interrelated and regulated by several neurohormonal mechanisms. Dysfunction of these mechanisms affects gastric emptying, pancreatic secretion and postprandial glycemia. Therefore, the present article reviews the neurohormonal-coupled mechanisms that control gastric emptying and pancreatic secretion and their plausible involvement in DGP. This will help in identification of novel therapeutic targets to treat DGP with minimal adverse effects on postprandial glycemia.