Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2018; 24(33): 3724-3737
Published online Sep 7, 2018. doi: 10.3748/wjg.v24.i33.3724
Long non-coding RNAs involved in metastasis of gastric cancer
Meng-Ting Lin, Hao-Jun Song, Xiao-Yun Ding
Meng-Ting Lin, Medical School of Ningbo University, Ningbo 315000, Zhejiang Province, China
Hao-Jun Song, Xiao-Yun Ding, Gastroenterology Department, Ningbo First Hospital, Ningbo 315000, Zhejiang Province, China
Author contributions: Lin MT wrote the paper; Song HJ and Ding XY revised this manuscript; all of the authors gave their approval of the final version.
Supported by the Natural Science Foundation of Ningbo, No. 2014A610226 and No.2016A610158; the Scientific Benefit for People Project of Ningbo, No. 2014C51001.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Xiao-Yun Ding, MD, PhD, Chief Doctor, Occupational Physician, Gastroenterology Department, Ningbo First Hospital, No. 59 Liu Ting Street, Haishu District, Ningbo 315000, Zhejiang Province, China.
Telephone: +86-574-87085588 Fax: +86-574-87291583
Received: April 25, 2018
Peer-review started: April 25, 2018
First decision: May 16, 2018
Revised: May 22, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: September 7, 2018
Core Tip

Core tip: This review summarizes the long noncoding RNAs (lncRNAs) that influence metastasis of gastric cancer. We classified lncRNAs according to their molecular mechanism, which included epithelial-mesenchymal transition, epigenetic regulation, degradation of the extracellular matrix, angiopoiesis, vasculogenic mimicry, and immunologic escape. Finally, we summarized the lncRNAs that have stable expression in serum and describe their clinical value. A table lists the clinical correlation of the lncRNAs in details.