Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2018; 24(29): 3273-3280
Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3273
High expression of type I inositol 1,4,5-trisphosphate receptor in the kidney of rats with hepatorenal syndrome
Jing-Bo Wang, Ye Gu, Ming-Xiang Zhang, Shun Yang, Yan Wang, Wei Wang, Xi-Ran Li, Yi-Tong Zhao, Hai-Tao Wang
Jing-Bo Wang, Ye Gu, Ming-Xiang Zhang, Yan Wang, Wei Wang, Xi-Ran Li, Yi-Tong Zhao, Liver Cirrhosis Ward, the Sixth People’s Hospital of Shenyang, Shenyang 110006, Liaoning Province, China
Shun Yang, Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning Province, China
Hai-Tao Wang, Department of General Surgery, the Second Affiliated Hospital of Shenyang Medical College, Shenyang 110002, Liaoning Province, China
Author contributions: Wang JB, Wang HT and Gu Y contributed equally to this work, and all of them were involved in the design and performing of the experiment, data analysis and drafting of the article; Zhang MX, Wang Y and Yang S participated in the study, hepatic and renal pathological examination and biochemical test; Li XR, Wang W and Zhao YT completed data analysis, Western blot analysis and real-time PCR and drafting of the paper.
Supported by Natural Science Foundation of Liaoning Province, No. 20170540826; Science and Technology Program of Shenyang City, No. 18-014-4-49; and Innovation Support Program of Shenyang City for Young and Middle-Aged Researchers, No. RC170051.
Institutional animal care and use committee statement: This study was approved by the Ethical Committee of the Sixth People’s Hospital of Shenyang.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Hai-Tao Wang, MSc, Surgeon, Department of General Surgery, the Second Affiliated Hospital of Shenyang Medical College, No. 20, Beijiuma Road, Heping District, Shenyang 110002, Liaoning Province, China.
Telephone: +86-18002452018 Fax: +86-24-31251510
Received: May 3, 2018
Peer-review started: May 4, 2018
First decision: June 6, 2018
Revised: June 19, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: August 7, 2018
Core Tip

Core tip: Type I inositol 1,4,5-trisphosphate receptor (IP3RI) protein expression is increased in the kidney of hepatorenal syndrome (HRS) rats, and IP3RI protein expression may be regulated at the transcriptional level. Increased expression of IP3RI may be closely associated with HRS development and progression through excessive renal vascular contraction resulting in insufficient renal blood perfusion.