Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2018; 24(28): 3145-3154
Published online Jul 28, 2018. doi: 10.3748/wjg.v24.i28.3145
Integrated genomic analysis for prediction of survival for patients with liver cancer using The Cancer Genome Atlas
Yan-Zhou Song, Xu Li, Wei Li, Zhong Wang, Kai Li, Fang-Liang Xie, Feng Zhang
Yan-Zhou Song, Department of General Surgery, Lianyungang Clinical Medical College of Nanjing Medical University/The First People’s Hospital of Lianyungang, Lianyungang 222002, Jiangsu Province, China
Xu Li, Feng Zhang, Department of Liver Surgery/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Wei Li, Zhong Wang, Kai Li, Fang-Liang Xie, Department of General Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, Jiangsu Province, China
Author contributions: Song YZ and Li X contributed equally to this work; Song YZ wrote the paper and performed the bioinformatic analysis; Li X performed the bioinformatic analysis and summarized the results; Li W, Wang Z, Li K collected and formatted genomic data; Xie FL revised the paper; Zhang F designed the research.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Nanjing Medical University.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The data in this manuscript was accessible through https://portal.gdc.cancer.gov/ or http://gdac.broadinstitute.org/
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Feng Zhang, MD, Professor, Department of Liver Surgery/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University; 300 Guangzhou Rd, Nanjing 210029, Jiangsu Province, China. doctorzhangfeng@njmu.edu.cn
Telephone: +86-13505145722 Fax: +86-25-83672106
Received: March 21, 2018
Peer-review started: March 22, 2018
First decision: April 24, 2018
Revised: June 13, 2018
Accepted: June 25, 2018
Article in press: June 25, 2018
Published online: July 28, 2018
Core Tip

© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

Core tip: The Cancer Genome Atlas (TCGA) is funded by the National Institute of Health to describe the genomic alterations across cancer types. Several months after the publication of liver cancer TCGA, we systemically evaluated the prognostic power of different omics data of liver cancer. We found that in all kinds of omics data in liver cancer, the mRNA data might be the most informative prognostic variable. The combination of clinical data with molecular data might be the future direction for cancer prognosis and prediction.