Published online Jun 7, 2018. doi: 10.3748/wjg.v24.i21.2211
Peer-review started: March 27, 2018
First decision: April 11, 2018
Revised: April 26, 2018
Accepted: May 11, 2018
Article in press: May 11, 2018
Published online: June 7, 2018
Core tip: Even though irritable bowel syndrome (IBS) is a common worldwide pediatric problem, little is known of its exact patho-physiology and management. Therefore, a large number of children are suffering from its intestinal and extra-intestinal symptoms. Novel research using new advanced technologies based on proposed top-down and bottom-up models of patho-physiology and treatment trials focusing on multiple combined interventions are likely to be more beneficial in understating and treating pediatric IBS. In addition, the time has come to explore possible prevention strategies for this problem.