Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis
Kirstine S Tølbøl, Maria NB Kristiansen, Henrik H Hansen, Sanne S Veidal, Kristoffer TG Rigbolt, Jacob Jelsing, Niels Vrang, Michael Feigh, Gubra Aps, Hørsholm DK-2970, Denmark
Kirstine S Tølbøl, Maria NB Kristiansen, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
Kirstine S Tølbøl, Matthew P Gillum, Section for Metabolic Imaging and Liver Metabolism, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark
Niels Vrang, Department of Chemistry, Faculty of Science, University of Copenhagen, Copenhagen DK-2200, Denmark
Author contributions: Tølbøl KS and Kristiansen MNB contributed equally to the work; Jelsing J, Vrang N and Feigh M designed the study; Tølbøl KS, Kristiansen MNB, Veidal SS and Rigbolt KTG acquired and analysed data; Tølbøl KS, Kristiansen MNB, Hansen HH, Veidal SS, Rigbolt KTG, Gillum MP, Jelsing J, Vrang N and Feigh M interpreted the data and contributed to writing the article, editing and reviewing, all authors approved the final version of the article.
Supported by Innovation Fund Denmark, KST; No. 5016-00168B; and MNBK, No. 5189-00040B.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (Licence No. 2013-15-2934-00784, The Animal Experiments Inspectorate, Denmark).
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kirstine S Tølbøl, MSc, Research Scientist, Gubra Aps, Hørsholm Kongevej 11B, Hørsholm DK-2970, Denmark. email@example.com
Received: September 25, 2017
Peer-review started: September 25, 2017
First decision: November 3, 2017
Revised: November 24, 2017
Accepted: December 5, 2017
Article in press: December 5, 2017
Published online: January 14, 2018