Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2018; 24(16): 1766-1778
Published online Apr 28, 2018. doi: 10.3748/wjg.v24.i16.1766
Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis
Shan-Shan Gong, Yi-Hong Fan, Shi-Yi Wang, Qing-Qing Han, Bin Lv, Yi Xu, Xi Chen, Yao-Er He
Shan-Shan Gong, Shi-Yi Wang, Qing-Qing Han, Xi Chen, Yao-Er He, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Yi-Hong Fan, Bin Lv, Yi Xu, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Gong SS and Wang SY performed the experiments, analyzed the data and wrote the paper; Fan YH and Han QQ designed the research, revised the paper and contributed equally to this study; Xu Y and Lv B performed parts of the experiments and provided valuable suggestions for this study; Chen X and He YE contributed new analytic tools; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81473506; Natural Science Foundation of Zhejiang Province, No.LY13H030011 and No. LY17H290009; State Administration of Traditional Chinese Medicine of Zhejiang Province, No. 2013ZB050; Department of Zhejiang Province to Build Funded Project, No. WKJ-ZJ-1531; Zhejiang TCM Science and Technology Project, No. 2016ZB047, No. 2017ZA056 and No. 2018ZB046.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Zhejiang Chinese Medical University.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Zhejiang Chinese Medical University.
Conflict-of-interest statement: No potential conflicts of interest exist.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Yi-Hong Fan, PhD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China.
Telephone: +86-571-87608001 Fax: +86-571-87608001
Received: February 12, 2018
Peer-review started: February 13, 2018
First decision: March 9, 2018
Revised: March 14, 2018
Accepted: March 31, 2018
Article in press: March 31, 2018
Published online: April 28, 2018
Core Tip

Core tip: Mucosal healing is a desired therapeutic endpoint in the treatment of inflammatory bowel disease. However, it is difficult to treat inflammatory bowel disease thoroughly, and there are some adverse reactions. Studies have shown that corticotropin-releasing hormone (CRH)-receptor (R)2 can activate the inflammatory response of intestinal mucosa and exert an antiinflammatory effect. Our preliminary study found that Tong-Xie-Yao-Fang could reduce the expression of CRH-R1, increase CRH-R2, and participate in reconstruction of the intestinal barrier. The aim of this study was to explore the significance of CRH-R2 in the mucosal healing of dextran sulfate sodium-induced colitis and study the effect of Tong-Xie-Yao-Fang on CRH-R2 expression and regulation.