Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis
Shan-Shan Gong, Shi-Yi Wang, Qing-Qing Han, Xi Chen, Yao-Er He, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Yi-Hong Fan, Bin Lv, Yi Xu, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Gong SS and Wang SY performed the experiments, analyzed the data and wrote the paper; Fan YH and Han QQ designed the research, revised the paper and contributed equally to this study; Xu Y and Lv B performed parts of the experiments and provided valuable suggestions for this study; Chen X and He YE contributed new analytic tools; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81473506; Natural Science Foundation of Zhejiang Province, No.LY13H030011 and No. LY17H290009; State Administration of Traditional Chinese Medicine of Zhejiang Province, No. 2013ZB050; Department of Zhejiang Province to Build Funded Project, No. WKJ-ZJ-1531; Zhejiang TCM Science and Technology Project, No. 2016ZB047, No. 2017ZA056 and No. 2018ZB046.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Zhejiang Chinese Medical University.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Zhejiang Chinese Medical University.
Conflict-of-interest statement: No potential conflicts of interest exist.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Hong Fan, PhD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. email@example.com
Telephone: +86-571-87608001 Fax: +86-571-87608001
Received: February 12, 2018
Peer-review started: February 13, 2018
First decision: March 9, 2018
Revised: March 14, 2018
Accepted: March 31, 2018
Article in press: March 31, 2018
Published online: April 28, 2018