Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2018; 24(10): 1167-1180
Published online Mar 14, 2018. doi: 10.3748/wjg.v24.i10.1167
Colonic lesion characterization in inflammatory bowel disease: A systematic review and meta-analysis
Richard Lord, Nicholas E Burr, Noor Mohammed, Venkataraman Subramanian
Richard Lord, Nicholas E Burr, Noor Mohammed, Venkataraman Subramanian, Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds LS97TF, United Kingdom
Richard Lord, Nicholas E Burr, Venkataraman Subramanian, University of Leeds, Leeds Institute of Biomedical and Clinical Sciences, Leeds LS97TF, United Kingdom
Author contributions: Subramanian V envisaged and designed the research; Subramanian V performed the statistical analysis; Lord R wrote the paper and did the information searching; Lord R and Burr NE performed the Selection of papers and data abstraction; Lord R and Mohammed N performed the study quality analysis; all authors have reviewed the manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Venkataraman Subramanian, CCST, MBBS, MD, MRCP, Assistant Professor, Department of gastroenterology, Leeds Teaching Hospitals NHS Trust, Beckett St, Leeds LS97TF, United Kingdom.
Telephone: +44-113-2068691 Fax: +44-113-2068688
Received: January 8, 2018
Peer-review started: January 9, 2018
First decision: February 5, 2018
Revised: February 18, 2018
Accepted: February 15, 2018
Article in press: February 15, 2018
Published online: March 14, 2018
Core Tip

Core tip:In vivo lesion characterization in colonic inflammatory bowel disease presents many challenges. Lesions tend to be morphologically different and potentially associated with surrounding/overlying inflammation, obscuring the pit pattern. The ability to accurately characterize lesions in vivo could reduce costs and complications by decreasing the need for polypectomies. Virtual chromoendoscopy (VCE) and dye-based chromoendoscopy currently cannot be recommended for lesion characterization. Confocal laser endomicroscopy is an accurate technology at differentiating neoplastic from non-neoplastic lesions but studies within this meta-analysis involved single expert center with single advanced endoscopic operators, reducing its generalizability. Larger studies are required specifically looking at lesion characterization, especially with rapid technological advancements in VCE (Narrow band imaging, i-scan, Fujinon intelligence chromoendoscopy).