Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells
Vaidotas Cesna, Giedrius Barauskas, Department of Surgery, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania
Arturas Sukovas, Saulius Paskauskas, Department of Obstetrics and Gynecology, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania
Aldona Jasukaitiene, Zilvinas Dambrauskas, Antanas Gulbinas, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania
Rima Naginiene, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania
Author contributions: Cesna V, Sukovas A analyzed the data and drafted the manuscript; Jasukaitiene A performed most of experiments; intracellular cisplatin concentration analysis was performed by Naginiene R; Barauskas G, Paskauskas S and Gulbinas A designed and coordinated the research; Gulbinas A and Dambrauskas Z revised the manuscript for important intellectual content; all authors have read and approved the final version to be published.
Supported by the Research Council of Lithuania, No. SEN-01/2015.
Institutional review board statement: The study was reviewed and approved by the Kaunas Regional Biomedical Research Ethics Committee.
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zilvinas Dambrauskas, MD, PhD, Lecturer, Professor, Surgeon, Lithuanian University of Health Sciences, Institute for Digestive Research, Eiveniu str., 4, Kaunas LT-50161, Lithuania. firstname.lastname@example.org
Telephone: +370-68-669255 Fax: +370-37-326179
Received: December 2, 2017
Peer-review started: December 2, 2017
First decision: December 27, 2017
Revised: January 2, 2018
Accepted: January 16, 2018
Article in press: January 16, 2018
Published online: March 14, 2018