Systematic Reviews
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2017; 23(9): 1697-1711
Published online Mar 7, 2017. doi: 10.3748/wjg.v23.i9.1697
Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review
Anne-Claire Desbois, Patrice Cacoub
Anne-Claire Desbois, Patrice Cacoub, Inflammation-Immunopathology-Biotherapy Department, Sorbonne Universités, 75005 Paris, France
Anne-Claire Desbois, Patrice Cacoub, UMR_S 959, French National Institute of Health and Medical Research, 75013 Paris, France
Anne-Claire Desbois, Patrice Cacoub, FRE3632, The French National Center for Scientific Research, 75005 Paris, France
Anne-Claire Desbois, Patrice Cacoub, Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, 75013 Paris, France
Author contributions: Desbois AC and Cacoub P designed research, contributed to new reagents or analytic tools, analyzed data, and wrote the paper; Desbois AC performed research.
Conflict-of-interest statement: Pr P. Cacoub has received consulting and lecturing fees from: Abbvie, Astra Zeneca, Bristol-Myers Squibb, Gilead, Glaxo Smith Kline, Janssen, and Merck Sharp Dohme. Dr AC Desbois has received lecturing fees from Gilead.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Patrice Cacoub, MD, PhD, professor, Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, 83 boulevard de l'hôpital, 75013 Paris, France. patrice.cacoub@aphp.fr
Telephone: +33-1-42178009 Fax: +33-1-42178033
Received: October 3, 2016
Peer-review started: October 7, 2016
First decision: October 28, 2016
Revised: November 10, 2016
Accepted: February 7, 2017
Article in press: February 8, 2017
Published online: March 7, 2017
Core Tip

Core tip: hepatitis C virus (HCV) infection is associated with increased rates of glucose abnormalities, including diabetes mellitus and insulin resistance. The presence of glucose abnormalities in HCV infected patients, including diabetes mellitus and insulin resistance, is associated with negative liver-related outcomes (i.e., severe liver fibrosis, decreased response to antivirals, and increased occurrence of hepatocellular carcinoma).