Prospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2017; 23(9): 1666-1675
Published online Mar 7, 2017. doi: 10.3748/wjg.v23.i9.1666
Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?
Xiao-Hua Chen, Ke Ren, Pan Liang, Ya-Ru Chai, Kui-Sheng Chen, Jian-Bo Gao
Xiao-Hua Chen, Pan Liang, Ya-Ru Chai, Jian-Bo Gao, Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Ke Ren, Surgery of Gastroenterology, Luohe Central Hospital, Luohe 462000, Henan Province, China
Kui-Sheng Chen, Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Chen XH and Ren K performed the research, data analysis and wrote the paper; Liang P contributed to the statistical analysis; Chai YR collected the data and assigned the forms; Chen KS performed the pathological examinations; Gao JB designed the research and contributed to the paper revisions.
Supported by the National Natural Science Foundation of China, No. 81271573.
Institutional review board statement: The study was reviewed and approved by the institutional review boards of the First Affiliated Hospital of Zhengzhou University.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian-Bo Gao, Professor, Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou 450052, Henan Province, China. jianbogaochina@163.com
Telephone: +86-371-67966890 Fax: +86-371-66970906
Received: November 24, 2016
Peer-review started: November 26, 2016
First decision: January 10, 2017
Revised: January 19, 2017
Accepted: February 7, 2017
Article in press: February 8, 2017
Published online: March 7, 2017
Core Tip

Core tip: We investigated the correlation between iodine concentration (IC) value generated from spectral computed tomography (CT) and angiogenesis in gastric cancer (GC) with clinical-pathological data. Our results showed that normalized IC (nIC) in both the arterial (AP) and venous phases (VP) had a positive linear correlation with micro-vessel density. nIC-AP reflected the angiogenesis in relatively earlier and well-differentiated GC, while nIC-VP reflected this in further advanced and poorly differentiated GC. Spectral CT with quantitative IC value offers a new choice for evaluating the angiogenesis of gastric cancer noninvasively.