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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2017; 23(8): 1375-1386
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1375
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1375
Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression
Nai-Ying Shen, Jian-Bin Bi, Jing-Yao Zhang, Si-Min Zhang, Jing-Xian Gu, Kai Qu, Chang Liu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Nai-Ying Shen, Department of General Surgery, Shaanxi Nuclear Geology 215 Hospital, Xianyang 712000, Shaanxi Province, China
Author contributions: Shen NY, Bi JB, and Zhang JY contributed equally to the work; Shen NY, Bi JB and Zhang JY participated in the research design and in the writing of the paper; Zhang SM participated in literature collection and performed WB; Gu JX participated in statistical analysis and performed IHC; Qu K participated in statistical analysis; Liu C was involved in designing this research, writing and revising the paper.
Supported by the Project of Innovative Research Team for Key Science and Technology in Shaanxi Province , No. 2013KCJ-23 ; the Fundamental Research Funds for the Central Universities , No. 1191320114 ; and the National Natural Science Foundation of China , No. 81601672 .
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of The First Affiliated Hospital of Xi’an Jiaotong University (IACUC protocol number: XJTULAC2014-207).
Conflict-of-interest statement: We declare that there is no conflict of interest regarding the publication of this article.
Data sharing statement: The authors declare no competing financial interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Telephone: +86-29-85323900 Fax: +86-29-85324642
Received: October 11, 2016
Peer-review started: October 13, 2016
First decision: December 2, 2016
Revised: December 20, 2016
Accepted: January 17, 2017
Article in press: January 17, 2017
Published online: February 28, 2017
Peer-review started: October 13, 2016
First decision: December 2, 2016
Revised: December 20, 2016
Accepted: January 17, 2017
Article in press: January 17, 2017
Published online: February 28, 2017
Core Tip
Core tip: Inflammatory bowel disease (IBD) is a chronic and relapsing disease primarily caused by the production of pro-inflammatory cytokines and leukocyte infiltration, resulting in structural and functional damage to the bowel. Hydrogen has obvious anti-oxidative and anti-inflammatory effects. We launched a study to investigate the protective role of hydrogen-rich water (HRW) on IBD in mice. The present study found that HRW has a significant therapeutic potential in IBD by inhibiting inflammatory factors, oxidative stress and endoplasmic reticulum stress and by up-regulating heme oxygenase-1 expression.