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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2017; 23(7): 1180-1188
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1180
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1180
Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation
Lie Zheng, Yan-Cheng Dai, Xuan Chen, De-Liang Chen, Yue-Ting Dai, Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Lie Zheng, Ya-Li Zhang, Zhi-Peng Tang, Institute of Digestive Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Zheng L and Zhang YL contributed equally to this work, and both performed the majority of experiments and analysis of the data; Dai YC, Chen X and Dai YT participated in the treatment of animals; Chen DL conducted the ELISA; Zheng L and Tang ZP designed and coordinated the research; Zheng L wrote and revised the paper.
Supported by the National Natural Science Foundation of China , No. 81403355 and No. 81573892 ; and the Project of 3-Year Action Plan for Shanghai Municipal Chinese Medicine Development , No. ZY3-RCPY-2-2001 .
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Shanghai University of Traditional Chinese Medicine (No. SZY 201510001).
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Peng Tang, MD, PhD, Professor, Director, Institute of Digestive Diseases, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai 200032, China. zhipengtang@sohu.com
Telephone: +86-21-64385700 Fax: +86-21-64385700
Received: June 30, 2016
Peer-review started: July 1, 2016
First decision: August 29, 2016
Revised: September 13, 2016
Accepted: October 10, 2016
Article in press: October 10, 2016
Published online: February 21, 2017
Peer-review started: July 1, 2016
First decision: August 29, 2016
Revised: September 13, 2016
Accepted: October 10, 2016
Article in press: October 10, 2016
Published online: February 21, 2017
Core Tip
Core tip: Nuclear factor-kappa B (NF-κB) is a major transcription factor inducing the expression of inflammatory mediators, which plays a crucial role in the transcription in diverse immune responses, and its signaling has been confirmed to be a major pathway for ulcerative colitis. It is demonstrated in the current study that Jianpi Qingchang decoction (JPQCD), which can decrease levels of proinflammatory cytokines, plays a role in inhibiting nuclear translocation of NF-κB and phosphorylation of inhibitor of kappa B, thus indicating that JPQCD can suppress the activation of NF-κB signaling pathway.