STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury
Mitsuhiko Abe, Takafumi Yoshida, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, Michio Sata, Hironori Koga, Takuji Torimura, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
Mitsuhiko Abe, Takafumi Yoshida, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, Michio Sata, Hironori Koga, Takuji Torimura, Liver Cancer Division, Research Center for Innovative Cancer Therapy, Kurume University, Kurume 830-0011, Japan
Takafumi Yoshida, Kurume Clinical Pharmacology Clinic, Kurume 830-0011, Japan
Jun Akiba, Department of Diagnostic Pathology, Kurume University Hospital, Kurume 830-0011, Japan
Akihiko Yoshimura, Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan
Author contributions: Abe M and Yoshida T contributed to study concept and design; Abe M, Yoshida T, Akiba J, Ikezono Y, Wada F, Masuda A, Sakaue T, Tanaka T, Iwamoto H and Nakamura T contributed to acquisition and analysis of data; Sata M and Koga H critically revised the manuscript; Sata M, Koga H, Yoshimura A and Torimura T supervised the study.
Supported by JSPS Grant-in-Aid for Scientific Research (C), No. 16K09385 to Torimura T.
Institutional review board statement: The study was reviewed and approved by Kurume University Genetic Recombination Experiments Committee.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by Kurume University Animal Experiment Committee (Approval number: 2014-184).
Conflict-of-interest statement: The authors have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Takafumi Yoshida, MD, PhD, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume Clinical Pharmacology Clinic.67 Asahi-Machi, Kurume 830-0011, Japan. firstname.lastname@example.org
Telephone: +81-942-317561 Fax: +81-942-342623
Received: January 18, 2017
Peer-review started: January 20, 2017
First decision: March 16, 2017
Revised: August 24, 2017
Accepted: September 6, 2017
Article in press: September 5, 2017
Published online: October 7, 2017