Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2017; 23(34): 6212-6219
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6212
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6212
Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer
Renate S Olsen, Division of Medical Diagnostics, Department of Laboratory Medicine, Region Jönköping County, SE-44185 Jönköping, Sweden
Renate S Olsen, Dick Wågsäter, Division of Drug Research, Department of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE-58185 Linköping, Sweden
Johnny Nijm, Division of Medical Diagnostics, Department of Clinical Physiology, Region Jönköping County, SE-44185 Jönköping, Sweden
Roland E Andersson, Department of Surgery, Region Jönköping County, SE-44185 Jönköping, Sweden
Roland E Andersson, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Linköping University, SE-58185 Linköping, Sweden
Jan Dimberg, Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, SE-55111 Jönköping, Sweden
Author contributions: All authors contributed to conception and design of the research, acquisition of data or analysis and interpretation of data; drafted the article and approved the version of the article to be published.
Supported by The Foundation of Clinical Cancer Research, Jönköping , No. 151124-6 ; and FORSS , the Research Council of Southeastern Sweden, No. FORSS-373251 .
Institutional review board statement: The study was approved by the Regional Ethical Review Board in Linköping, Linköping, Sweden.
Informed consent statement: Written informed consent was obtained from each patient.
Conflict-of-interest statement: The authors have no conflict of interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Dick Wågsäter, Professor, Division of Drug Research, Department of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, SE-58185 Linköping, Sweden. dick.wagsater@liu.se
Telephone: +46-10-1032058 Fax: +46-13-149403
Received: February 3, 2017
Peer-review started: February 9, 2017
First decision: April 21, 2017
Revised: May 12, 2017
Accepted: July 12, 2017
Article in press: July 12, 2017
Published online: September 14, 2017
Peer-review started: February 9, 2017
First decision: April 21, 2017
Revised: May 12, 2017
Accepted: July 12, 2017
Article in press: July 12, 2017
Published online: September 14, 2017
Core Tip
Core tip: Plasma levels of 40 different cytokines, chemokines and interleukins were analyzed in colorectal cancer (CRC) patients of which high tertile levels of nine factors were associated with total mortality and six factors with CRC-specific mortality. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery.