Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2017; 23(33): 6088-6099
Published online Sep 7, 2017. doi: 10.3748/wjg.v23.i33.6088
Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocin- induced diabetes in the pig
Michał Bulc, Katarzyna Palus, Łukasz Zielonka, Magdalena Gajęcka, Jarosław Całka
Michał Bulc, Katarzyna Palus, Jarosław Całka, Department of Clinical Physiology Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-719 Olsztyn, Poland
Łukasz Zielonka, Magdalena Gajęcka, Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland
Author contributions: Bulc M designed the study, collected and analysed the data and drafted the manuscript; Palus K provided statistical oversight and revised the manuscript; Zielonka Ł and Gajęcka M contributed to reagents/materials/analysis tools; Całka J contributed to the substantive and language correction; all authors have read and approved the final version to be published.
Supported by a statutory Grant No. 528-0523.0802; and KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal-Safe Food”, decision of Ministry of Science and Higher Education, No. 05-1/KNOW2/2015.
Institutional review board statement: The study was reviewed and approved by the Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn Institutional Review Board.
Institutional animal care and use committee statement: All procedure involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Local Ethical Committee in Olsztyn (Poland) (No. 13/2015/DTN).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michał Bulc, DVM, Assistant Professor, Department of Clinical Physiology Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Str. 13, 10-719 Olsztyn, Poland. michal.bulc@uwm.edu.pl
Telephone: +48-89-5234461
Received: April 20, 2017
Peer-review started: April 27, 2017
First decision: June 8, 2017
Revised: July 21, 2017
Accepted: August 2, 2017
Article in press: August 2, 2017
Published online: September 7, 2017
Core Tip

Core tip: Our results revealed the neuronal plasticity of enteric neurons within porcine stomach in response to chronic hyperglycemia. We used the pig as a model for human gastrointestinal disorders occurring in people with diabetes. Our study highlights the important role of the enteric nervous system in response to high glucose serum level. We observed a substantial increase in the expression of nitric oxide, galanin and vasoactive intestinal peptide inside the enteric neurons. Since all of the investigated molecules have inhibitory properties, they may be involved in the impairment of the motor function of the stomach occurring in people with long-term diabetes.