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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2017; 23(29): 5333-5344
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5333
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5333
Salvianolic acid B protects hepatocytes from H2O2 injury by stabilizing the lysosomal membrane
Xiao-Feng Yan, Pei Zhao, Xiao-Ling Wang, Department of Biology, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Dong-Yan Ma, Women and Infant Hospital of Zhengzhou, Zhengzhou 450000, Henan Province, China
Yi-Lu Jiang, Jiao-Jiao Luo, Liu Liu, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Author contributions: Wang XL and Yan XF designed the research; Yan XF, Zhao P, Ma DY, Jiang YL, Luo JJ and Liu L performed the research; Yan XF, Zhao P and Ma DY analyzed the data; Wang XL wrote the paper.
Supported by National Natural Science Funds of China , No. 81503367 ; and the Budget Research Project of Shanghai Education Commission , No. 2014YSN03 and No. 2014YSN22 .
Institutional review board statement: This study was reviewed and approved by the Shanghai University of Traditional Chinese Medicine Institutional Review Board (No. 201409011).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Shanghai University of Traditional Chinese Medicine [License number: SCXK (Shanghai) 2014-0008].
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiao-Ling Wang, Department of Biology, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China. wangxiaoling1033@shutcm.edu.cn
Telephone: +86-21-51322585
Received: January 17, 2017
Peer-review started: January 19, 2017
First decision: February 23, 2017
Revised: March 27, 2017
Accepted: May 9, 2017
Article in press: May 9, 2017
Published online: August 7, 2017
Peer-review started: January 19, 2017
First decision: February 23, 2017
Revised: March 27, 2017
Accepted: May 9, 2017
Article in press: May 9, 2017
Published online: August 7, 2017
Core Tip
Core tip: Lysosomal membrane permeabilization leads to the release of luminal contents, such as proteases and protons, into the cytosol, resulting in cell death. Salvianolic acid B (Sal B), a water-soluble compound extracted from Salvia miltiorrhiza, exerts a cell protective effect by anti-oxidation. In the present study, we elucidate that Sal B protects hepatocytes from H2O2/CCl4 -induced injury/death by stabilizing the lysosomal membrane.