Meta-Analysis
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2017; 23(27): 5018-5033
Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.5018
High expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: Result of a meta-analysis
Qi Huang, Shu Li, Pu Cheng, Mei Deng, Xin He, Zhen Wang, Cheng-Hui Yang, Xiao-Ying Zhao, Jian Huang
Qi Huang, Pu Cheng, Mei Deng, Zhen Wang, Cheng-Hui Yang, Jian Huang, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Shu Li, Xin He, Xiao-Ying Zhao, Department of Hematology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Li S, Cheng P and Deng M reviewed and screened the articles included in our meta-analysis; Huang Q and He X performed the analysis work needed in this work and draft the manuscript; Wang Z and Yang CH drew the essential diagrams; Zhao XY and Huang J designed the study and edited the manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian Huang, MD, PhD, Professor, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Jiefang88 Road, Hangzhou 310009, Zhejiang Province, China. drhuangjian@zju.edu.cn
Telephone: +86-571-87784642 Fax: +86-571-87784642
Received: February 7, 2017
Peer-review started: February 8, 2017
First decision: February 8, 2016
Revised: March 5, 2017
Accepted: April 21, 2017
Article in press: April 21, 2017
Published online: July 21, 2017
Core Tip

Core tip: No consensus is available in the literature about the prognostic value of Bcl-2 expression in patients with colorectal cancer (CRC). This is the first systematic review and meta-analysis indicating that Bcl-2 is a good prognostic factor in CRC. We investigated the relation in terms of overall survival, disease free survival/recurrent free survival, number of patients, nations, therapy methods, pathological grade.