Randomized Clinical Trial
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2017; 23(24): 4454-4461
Published online Jun 28, 2017. doi: 10.3748/wjg.v23.i24.4454
Comparing reduced-dose sodium phosphate tablets to 2 L of polyethylene glycol: A randomized study
Soichiro Ako, Koji Takemoto, Eriko Yasutomi, Chihiro Sakaguchi, Mayu Murakami, Tomoko Sunami, Shohei Oka, Hamada Kenta, Noriko Okazaki, Yuki Baba, Yasushi Yamasaki, Toshiyuki Asato, Daisuke Kawai, Ryuta Takenaka, Hirohumi Tsugeno, Sakiko Hiraoka, Jun Kato, Shigeatsu Fujiki
Soichiro Ako, Koji Takemoto, Eriko Yasutomi, Chihiro Sakaguchi, Mayu Murakami, Tomoko Sunami, Shohei Oka, Hamada Kenta, Noriko Okazaki, Yuki Baba, Yasushi Yamasaki, Toshiyuki Asato, Daisuke Kawai, Ryuta Takenaka, Hirohumi Tsugeno, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama City, Okayama 708-0841, Japan
Soichiro Ako, Sakiko Hiraoka, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Jun Kato, Second Department of Internal Medicine, Wakayama Medical University, Wakayama city, Wakayama 641-8509, Japan
Author contributions: Ako S, Takemoto K contributed to the study conception and design; Yasutomi E, Sakaguchi S, Murakami M, Sunami T, Oka S, Kenta H, Okazaki N, Baba Y, Yamasaki Y, Asato T, Kawai D, Takenaka R and Tsugeno H contributed to data acquisition; Hiraoka S, Kato J and Fujiki S contributed to drafting the manuscript and revising; all authors have given final approval of the version to be published.
Conflict-of-interest statement: There are no conflict-of-interests involved in the article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Soichiro Ako, MD, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. soichiro.ako@gmail.com
Telephone: +81-86-2357219 Fax: +81-86-2357219
Received: December 28, 2016
Peer-review started: December 30, 2016
First decision: February 9, 2017
Revised: March 1, 2017
Accepted: March 30, 2017
Article in press: March 30, 2017
Published online: June 28, 2017
Core Tip

Core tip: Colonoscopy is indispensable for the diagnosis and treatment of colorectal diseases. However, colonoscopy inevitably requires bowel preparation, which is sometimes burdensome to patients. We conducted a randomized clinical trial of the bowel preparation to seek the better tolerability and quality. We compared 2 L polyethylene glycol (PEG) and 30 sodium phosphate (NaP) tablets. Total 200 patients were randomly assigned to each group. We found that the cleansing quality was better in the PEG group, and NaP showed better tolerability. Especially in females of < 50 years of age, NaP was associated with better tolerability and equivalent bowel cleansing quality.