Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2017; 23(19): 3505-3512
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3505
Clinical course of ulcerative colitis patients who develop acute pancreatitis
Jong Wook Kim, Sung Wook Hwang, Sang Hyoung Park, Tae Jun Song, Myung-Hwan Kim, Ho-Su Lee, Byong Duk Ye, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
Jong Wook Kim, Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang 10380, South Korea
Sung Wook Hwang, Sang Hyoung Park, Tae Jun Song, Myung-Hwan Kim, Byong Duk Ye, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea
Ho-Su Lee, Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, South Korea
Author contributions: Kim JW and Hwang SW contributed equally to this work and should be regarded as co-first authors; Kim JW wrote the manuscript; Hwang SW acquired and analysed the data; Park SH, Song TJ, Kim MH, Lee HS, Ye BD, Yang DH, Kim KJ, Byeon JS and Myung SJ generated the data; Yang SK had the original idea for the paper, gave critical comments, and revised the manuscript; all authors approved the final version of the manuscript.
Supported by Korean Health Technology R and D Project, Ministry of Health and Welfare, South Korea, No. A120176.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Asan Medical Center (IRB No. 2016-0688).
Informed consent statement: Patients provided informed verbal consent to participate in this study. All clinical data were obtained anonymously and innocuously.
Conflict-of-interest statement: Suk-Kyun Yang received a research grant from Janssen Korea Ltd., but this grant is not related to the current study topic. The remaining authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Suk-Kyun Yang, MD, PhD, Professor, Chief, Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. sky@amc.seoul.kr
Telephone: +82-2-30103901 Fax: +82-2-4760824
Received: January 16, 2017
Peer-review started: January 16, 2017
First decision: February 9, 2017
Revised: March 17, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: May 21, 2017
Core Tip

Core tip: Clinical course of ulcerative colitis (UC) patients who develop acute pancreatitis is not well known. In a large prospectively maintained inflammatory bowel disease cohort at Asan Medical Center, we found 51 cases of acute pancreatitis among 3,307 UC patients. Among these, there were 13 (0.4%) patients with autoimmune, 10 (0.3%) with aminosalicyte-induced, and 13 (1.73%) with thiopurine-induced pancreatitis, whose colectomy rates were 15.4% (2/13), 20% (2/10), and 15.4% (2/13), respectively. The colectomy rate for non-pancreatitis patients was 7.3% (239/3256), which was not significantly different from those of acute pancreatitis patients, after adjusting for baseline extent.