Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2017; 23(19): 3488-3495
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3488
Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study
Yasushi Adachi, Masanori Nojima, Mitsuru Mori, Kentaro Yamashita, Hiro-o Yamano, Hiroshi Nakase, Takao Endo, Kenji Wakai, Kiyomi Sakata, Akiko Tamakoshi
Yasushi Adachi, Takao Endo, Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakaba-dai Hospital, Sapporo 062-0052, Japan
Yasushi Adachi, Kentaro Yamashita, Hiro-o Yamano, Hiroshi Nakase, Department of Gastroenterology, Sapporo Medical University, Sapporo 060-8543, Japan
Masanori Nojima, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo 108-8639, Japan
Mitsuru Mori, Department of Public Health, Sapporo Medical University, School of Medicine, Sapporo 060-8556, Japan
Kenji Wakai, Department of Preventive Medicine, Nagoya University, Graduate School of Medicine, Nagoya 466-8550, Japan
Kiyomi Sakata, Department of Hygiene and Preventive Medicine, Iwate Medical University School of Medicine, Yahaba 028-3694, Japan
Akiko Tamakoshi, Department of Public Health, Hokkaido University School of Medicine, Sapporo 060-8638, Japan
Author contributions: Adachi Y analyzed data and wrote the manuscript; Nojima M analyzed data and corrected the manuscript; Yamashita K, Yamano H, and Nakase H advised and checked the manuscript; Endo T helped this study and to write the manuscript; Mori M, Wakai K, Sakata K and Tamakoshi A are the original members of JACC study and advised for this study.
Supported by the Ministry of Education, Culture, Sports, Science, and Technology and from the Ministry of Health, Labour and Welfare, Japan.
Institutional review board statement: The ethical board of the Nagoya University School of Medicine approved this study.
Informed consent statement: Informed consent was obtained from all participants.
Conflict-of-interest statement: The authors have declared no conflicts of interest.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yasushi Adachi, MD, PhD, Department of Gastroenterology, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan. yadachi@sapmed.ac.jp
Telephone: +81-11-6112111 Fax: +81-11-6112282
Received: December 29, 2016
Peer-review started: January 3, 2017
First decision: February 10, 2017
Revised: February 25, 2017
Accepted: April 21, 2017
Article in press: April 21, 2017
Published online: May 21, 2017
Core Tip

Core tip: Insulin-like growth factor-1 (IGF1) is a potent mitogen, whereas IGF-binding protein-3 (IGFBP3) binds and inhibits IGF1. High circulating IGF1 and low IGFBP3 are associated with increased risk of several cancers. Here we assessed the relationship between these molecules and the risk of esophageal carcinoma in a prospective, nested case-control study from the Japan Collaborative Cohort Study. Free IGF1, represented by the molar ratio of IGF1/IGFBP3, was not correlated with the risk of esophageal carcinoma. The free form of IGFBP3, which is estimated by the molar difference of IGFBP3-IGF1, may be inversely associated with esophageal cancer incidence.