Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2017; 23(18): 3262-3268
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3262
Artificial liver support in pigs with acetaminophen-induced acute liver failure
Guo-Lin He, Lei Feng, Lei Cai, Chen-Jie Zhou, Yuan Cheng, Ze-Sheng Jiang, Ming-Xin Pan, Yi Gao
Guo-Lin He, Lei Feng, Lei Cai, Chen-Jie Zhou, Yuan Cheng, Ze-Sheng Jiang, Ming-Xin Pan, Yi Gao, Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Author contributions: Pan MX and Gao Y designed the research; He GL, Zhou CJ, Cheng Y, Jiang ZS and Gao Y performed the research; He GL, Zhou CJ and Cheng Y analyzed the data; He GL wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Zhujiang Hospital Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Guangdong Province [IACUC protocol number: SCXK (Guangdong) 2011-0015].
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yi Gao, Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, No. 253 Gongye Road, Haizhu District, Guangdong Province, Guangzhou 510280, Guangdong Province, China. gaoyizjyy@126.com
Telephone: +86-20-62782560 Fax: +86-20-61643207
Received: December 6, 2016
Peer-review started: December 6, 2016
First decision: December 29, 2016
Revised: January 24, 2017
Accepted: March 20, 2017
Article in press: March 20, 2017
Published online: May 14, 2017
Core Tip

Core tip: This is an article about an artificial liver system that was used to treat an acetaminophen (APAP)-induced porcine acute liver failure (ALF) model. An APAP porcine ALF model was developed and treated with an artificial liver system. The artificial liver system (ZHJ-3) improved serum biochemistry levels and extended porcine survival times significantly. This study concluded that the APAP-induced model is reproducible and allows for quantitative evaluation of new liver systems, such as a bioartificial liver, for the support of hepatic failure in humans. The artificial liver system (ZHJ-3) is safe and effective for the APAP-induced porcine ALF model.