Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2017; 23(17): 3150-3162
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3150
Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease
Chiara Gelli, Mirko Tarocchi, Ludovico Abenavoli, Laura Di Renzo, Andrea Galli, Antonino De Lorenzo
Chiara Gelli, Laura Di Renzo, Antonino De Lorenzo, Division of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 0133 Rome, Italy
Chiara Gelli, Mirko Tarocchi, Andrea Galli, Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy
Ludovico Abenavoli, Department of Health Sciences, University Magna Graecia, Campus Germaneto, 88100 Catanzaro, Italy
Author contributions: Gelli C and Tarocchi M contributed equally to this work; Gelli C and Tarocchi M designed and performed the research; Gelli C wrote the manuscript; Tarocchi M, Di Renzo L, De Lorenzo A, Galli A and Abenavoli L reviewed and edited the manuscript; all authors read and approved the manuscript.
Supported by Fondo per gli Investimenti della Ricerca di Base, No. RBAP10MY35_002; Ente Cassa di Risparmio di Firenze; and FiorGen ONLUS to Galli A.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee “Centro, RC” n.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors confirm that this article content has no conflict of interest.
Data sharing statement: Dataset available from the corresponding author at mirko.tarocchi@unifi.it.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Mirko Tarocchi, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy. mirko.tarocchi@unifi.it
Telephone: +39-55-2758115 Fax: +39-55-2758119
Received: December 20, 2016
Peer-review started: December 22, 2016
First decision: January 10, 2017
Revised: February 13, 2017
Accepted: April 13, 2017
Article in press: April 13, 2017
Published online: May 7, 2017
Core Tip

Core tip: Most recent advances in the management and treatment of Non-alcoholic fatty liver disease (NAFLD) show that a multifaceted approach is likely to achieve the best outcomes. Our study evaluates the effectiveness of 6-mo multidisciplinary approach jointly carried out by a gastroenterologist and a nutritionist with counseling license. The approach was effective on the reduction of NAFLD severity, weight, anthropometric indexes, cardiovascular disease risk factors and the normalization of metabolic index, as well as liver enzymes. This study strengthens the hypothesis that MedDiet and more active lifestyle can be considered a safe therapeutic approach for reducing severity of NAFLD.