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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2017; 23(16): 3003-3010
Published online Apr 28, 2017. doi: 10.3748/wjg.v23.i16.3003
Published online Apr 28, 2017. doi: 10.3748/wjg.v23.i16.3003
Protein-losing pseudomembranous colitis with cap polyposis-like features
Wolfgang Kreisel, Bertram Bengsch, Anna-Maria Globig, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Guenther Ruf, Department of General and Visceral Surgery, Center for Surgery, University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Richard Salm, Department of Surgery, RKK Bruder-Klaus-Krankenhaus, 79183 Waldkirch, Germany
Adhara Lazaro, Institute for Exercise and Occupational Medicine, Center for Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Paul Fisch, Silke Lassmann, Annette Schmitt-Graeff, Institute of Surgical Pathology, Medical Center and Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Author contributions: Kreisel W designed the report and was responsible for therapy; Ruf G performed the surgical procedures (i.e ., resection of rectum and sigmoid colon, descendostomy, and reanastomosis); Salm R did the mucosal resection of the remaining distal rectum; Lazaro A contributed in drafting this article; Bengsch B and Globig AM analyzed the subgroups of lymphocytes in the peripheral blood and in the colonic biopsies; Fisch P performed molecular pathology clonality analyses; Lassmann S performed molecular pathology NGS analyses; Schmitt-Graeff A evaluated the biopsy specimens and contributed in designing this case report.
Institutional review board statement: Ethics Commission, Universitätsklinikum Freiburg, 79106 Freiburg, Germany.
Informed consent statement: The patient whose clinical course was described gave a written informed consent for this publication.
Conflict-of-interest statement: There was no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wolfgang Kreisel, MD, Professor, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. wolfgang.kreisel@uniklinik-freiburg.de
Telephone: +49-761-27034010 Fax: +49-761-27074880
Received: January 27, 2017
Peer-review started: February 3, 2017
First decision: February 23, 2017
Revised: March 11, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: April 28, 2017
Peer-review started: February 3, 2017
First decision: February 23, 2017
Revised: March 11, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: April 28, 2017
Core Tip
Core tip: Protein-losing enteropathy (PLE) is characterized by loss of serum proteins into the gastrointestinal tract. The small intestine is the most common site of protein loss. This is an unusual case of severe PLE involving the sigmoid colon and the rectum. Surgical resection was performed and subsequent histologic evaluation confirmed a diagnosis of a pseudomembranous colitis with cap polyposis-like features.