Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2017; 23(12): 2234-2245
Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2234
Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis
Xiao-Wei Zhang, Jun Li, Yu-Xing Jiang, Yu-Xiang Chen
Xiao-Wei Zhang, Jun Li, Yu-Xiang Chen, Department of Gastrointestinal and Vascular Surgery, Deyang People’s Hospital, Deyang 618099, Sichuan Province, China
Yu-Xing Jiang, Department of General Surgery and Center for Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Author contributions: Zhang XW and Chen YX conceived and designed the study; Li J and Jiang YX designed the data extraction tool and conducted the literature search; Zhang XW and Li J interpreted and extracted the data; Zhang XW, Li J and Jiang YX performed the statistical analysis; Zhang XW and Li J wrote the first draft of the manuscript; Jiang YX and Chen YX contributed to the revision of the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Yu-Xiang Chen, Chief Physician, Department of Gastrointestinal and Vascular Surgery, Deyang People’s Hospital, Deyang 618099, Sichuan Province, China.
Telephone: +86-838-2418116 Fax: +86-838-2418116
Received: December 6, 2016
Peer-review started: December 8, 2016
First decision: February 9, 2017
Revised: February 26, 2017
Accepted: March 4, 2017
Article in press: March 4, 2017
Published online: March 28, 2017
Core Tip

Core tip: To explore the association of the cyclooxygenase-2 (COX-2) (-1195G>A) polymorphism with gastrointestinal cancers, we conducted this retrospective study. According to this meta-analysis, we discovered that the COX-2 (-1195G>A) polymorphism may be a risk factor for gastrointestinal cancers and may increase the risk of gastrointestinal cancers in the Asian population. Furthermore, we applied a false-positive report probability to make the results more credible. Our findings indicated that focusing on the COX-2 (-1195G>A) polymorphism to prevent gastrointestinal cancers may be viable.