Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2017; 23(11): 2012-2022
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.2012
Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer
Yu-Qin Sun, Jian-Wei Xie, Hong-Teng Xie, Peng-Chen Chen, Xiu-Li Zhang, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Long-Long Cao, Chang-Ming Huang, Yao Lin
Yu-Qin Sun, Hong-Teng Xie, Peng-Chen Chen, Xiu-Li Zhang, Yao Lin, College of Life Sciences, Fujian Normal University, Fuzhou 350108, Fujian Province, China
Yu-Qin Sun, Jian-Wei Xie, Hong-Teng Xie, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Long-Long Cao, Chang-Ming Huang, Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Author contributions: Sun YQ and Xie JW contributed equally to this article; Huang CM and Lin Y conceived and designed the study; Sun YQ, Xie JW, Xie HT, Chen PC and Zhang XL performed the experiments; Zheng CH, Li P, Wang JB, Lin JX and Cao LL analyzed and interpreted the data; Sun YQ and Xie JW drafted the manuscript.
Supported by National Natural Science Foundation of China, No. 81441123 (to Huang CM), No. 31640053 (to Lin Y); National Key Clinical Specialty Discipline Construction Program of China, No. [2012]649; Key Scientific and Technological Project of Fujian Province, China, No. 2014Y0025 (to Huang CM); and Natural Science Foundation of Fujian Province, China, No. 2014J01322 (to Xie JW), No. 2016Y0029 (to Lin Y).
Conflict-of-interest statement: The authors declare that no conflict of interest exists.
Data sharing statement: All available data can be obtained by contacting the corresponding author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yao Lin, Professor, College of Life Sciences, Fujian Normal University, Qishan Campus, Fuzhou 350108, Fujian Province, China. yaolin@fjnu.edu.cn
Telephone: +86-591-22868688
Received: November 3, 2016
Peer-review started: November 4, 2016
First decision: December 28, 2016
Revised: December 30, 2016
Accepted: January 4, 2017
Article in press: January 4, 2017
Published online: March 21, 2017
Core Tip

Core tip: Our study shows that low expression of chromosomal maintenance (CRM)1 and cyclin-dependent kinase (CDK)5 was associated with poor prognosis of gastric cancer patients. The expression of CRM1 or CDK5 influenced the prognostic value of each other. Combined CRM1 and CDK5 expression had better prognostic power than their individual expression had.