Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2016; 22(42): 9378-9386
Published online Nov 14, 2016. doi: 10.3748/wjg.v22.i42.9378
Folfirinox in elderly patients with pancreatic or colorectal cancer-tolerance and efficacy
Jean-Florian Guion-Dusserre, Aurélie Bertaut, François Ghiringhelli, Julie Vincent, Valérie Quipourt, Sophie Marilier, Zoé Tharin, Leila Bengrine-Lefevre
Jean-Florian Guion-Dusserre, Aurélie Bertaut, François Ghiringhelli, Julie Vincent, Valérie Quipourt, Sophie Marilier, Zoé Tharin, Leila Bengrine-Lefevre, Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France
François Ghiringhelli, Julie Vincent, Institut National de la Santé et de la Recherche Médicale, University of Burgundy, 21078 Dijon, France
Author contributions: Guion-Dusserre JF performed the research; Guion-Dusserre JF, Bertaut A and Bengrine-Lefevre L analyzed the data; Guion-Dusserre JF, Ghiringhelli F and Bengrine-Lefevre L wrote the paper; Ghiringhelli F and Bengrine-Lefevre L designed the research; Vincent J, Quipourt V, Marilier S and Bengrine-Lefevre L contributed to providing patients data; Tharin Z helped for translation.
Institutional review board statement: This study was approved by the local insitutional review board.
Informed consent statement: I declare that all patients give written inform consent to participate in clinical research before receiving any therapy.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Francois Ghiringhelli, MD, PhD, Department of Medical Oncology, Centre Georges François Leclerc, INSERM Avenir 866, 1, rue du Professeur Marion, 21000 Dijon, France.
Telephone: +33-380-737500 Fax: +33-380-737500
Received: June 30, 2016
Peer-review started: July 1, 2016
First decision: July 29, 2016
Revised: August 14, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 14, 2016
Processing time: 134 Days and 17.5 Hours
Core Tip

Core tip: The incidence of cancer in patients over 70 years old is still increasing, especially for pancreatic and colorectal cancer. Database is missing concerning elderly patients, especially for considered aggressive chemotherapies, like FOLFIRINOX. The aim of this retrospective study was to show the feasibility of a combination chemotherapies (FOLFIRINOX) in an elderly population, by initially adapting the treatment dose, according to the patient’s general condition and comorbidities. We surprisingly observed prolonged survival and manageable toxicity levels.